Yes cut direction is something to consider, as looking at the mill I placed my tools on the left hand side, don't know why I did this, but required me to do buy reverse rotation drill bits so the spindle would not have to stop after turning in reverse. Didn't do any tool offsets or any of that stuff, used a dial indicator and mapped out the tooling, then programmed the move heights in my self. You also have to prgram for Z axis backlash as you move around up and down. Took me forever to visualize with my minds eye every Z axis reversal and where to add or subract .0015" of backlash in the z. Otherwise things would rub.
BlueFin CNC LLC
Southern Oregon