Since your using Spindle Talker I'm going assume your using a typical Chinese spindle, and since your able to run spindle with Spindle Talker we can eliminate noise. Do make sure you have latest version of UCCNC, I never tested on any version lower than 1.2029. This sounds like a settings issue, did you go to the configure window and set up per instructions? Are you getting a connected window on start up? Make sure your pulley checkbox in spindle set up in UCCNC is unchecked.
I'm going to post a newer version, it's really the same Plugin but the pulley system is implemented. My reason for prematurely releasing is that it retains settings in use to view when you go back to the configure window. Once loaded and restarted confirm it is properly set up with com port, baud rate, max frequency and max RPM. Make sure pulley system is unchecked.
Dan
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