I've recently upgraded my old MDF, skateboard bearings and threaded rod CNC router to one that is driven by a 16mm trapezoidal leadscrew with steel nuts. However, I have severely overestimated the alignment tolerances of the axes. Even a tiny amount of misalignment causes the leadscrew to bind in the nut which stalls my puny steppers. I've managed (after many hours) to get two of the axes to play ball but my Y axis still binds. I know why it binds - poor design on my part - and there is not much I can do about it save for a radical redesign which will take months!
Anyway, I was thinking, would it make sense to get some acetal/delrin/nylon nuts made to replace the steel ones? My gut feeling is that these would be much more tolerant to misalignment than steel nuts.