I don't use those, but I think that rack and pinion users are getting between 30-70i/s/s accel rates in Mach3. You might be able to get a bit higher rates due to the higher mechanical advantage.
When you start getting into higher speeds, steppers start to rapidly lose their appeal. Not only do you have to trade velocity for acceleration, you also have to start giving up resolution as you go faster.
I'm currently working (very slowly) on a dual spindle router. I was originally going to use the 570oz motors with a r&p type setup, but have since decided to go with 400w AC servos, which will give high acceleration, high velocity, and high resolution. The downside will be the high cost.
50lbs is probably far more cutting force than you'll encounter with the spindle you'll be using. 30-50lbs is usually a safe estimate.
I was talking about your X axis rails. I assumed they were supported? If not, you're going to see a LOT of flex in them. Yes profile rails are far superior. There are some chinese versions available that can be had for maybe double the cost of the round rails. Or, careful Ebay shopping can get them for even less.
No, you can't daisy chain G540's, but you can use another parallel port to add additional drives and motors, as well as additional inputs and outputs.