That argument doesn't seem terribly compelling to me. Nothing you hold in a vise is going to come anywhere near the physical limits of travel of any good-sized machine. Only a large part or fixture bolted to the table will.
For maximum flexibility, you'd really want the spindle to be forward of the center-point of Y axis travel, to allow plenty of rear over-hang. In reality, many, if not most, machines I've seen have just the opposite.
Regards,
Ray L.