Hi resolution is not for daily use, and it will damage your eyes. Long term trigers damage beyond repair
Decrease resolution, adjust toolbars to only necesary, and increase distance from monitor, at least 3..4 diagonals
Pause 10 5 or at least 3 minutes each hour, and look in the distance, as eyes will rest if what they see is not in near focus.
Your request for bigger pointer may be an early sign of something