Cube3
I can't answer for steppers, but with servos and ballscrews, the answer is no for a couple of reasons.
First, you indicated ballscrews and that means you will have to turn off the servos in order to move the axis. Then with very little force, the axis can be "back driven" and you will loose your position.
Secondly, you can't move the axis with the servos on. It will lock them in place.
On my machine, I lost the hand wheels entirely and haven't looked back since. For manual operation, I either use the MDI mode and enter the appropriate command or use the jog screen to move around using the keyboard keys.
Another option would be to make/obtain a MPG (manual pulse generator) and use that knob to move an axis.
Art
AKA Country Bubba (Older Than Dirt)