You must remember that as soon as the valve is opened and air flows, there will be a drop in pressure.
The last shop I worked at plumbed the shop with plastic tubing that was approximately 5/16 ID. That was fine for all of those using an air nozzle to blow something off, but every time the newly installed Haas mills would change tools, we would get low air pressure alarms. Believe it or not it took me about 2 months to get them to change.
Air flowing through lines is just like any gas or liquid, there is friction to the flow and if you have 100 PSI at the compressor and run it through 100 feet of line, you will only get maybe 80 PSI out of the end of it at best.
Supply more and let the regulator control it. Use large lines whenever possible. I always plumb my shops with PVC of 1/2 inch or better.
Think of it like your water hose at your house. When you first open the spray nozzle it has a little bit more force than a split second or so later. That is friction at work. If you ran that same water through a hose that was 1000 feet long, you would get very little flow out of it at the end.
Cheers---Mike
Two Haas VF-2's, Haas HA5C, Haas HRT-9, Hardinge CHNC 1, Bother HS-300 Wire EDM, BobCAD V23, BobCAD V28