Hi Milke,
As a newbie with no machinist knowledge but plenty of electronics and lab experience, I've been forced to use the local hardware as a major source of raw material.
For me small means a small workpiece, so it makes sense to move the work not the spindle. I'm heading for a 2.5D axis setup with the z axis movement of the workpiece coming from a separately controlled arm. But I would put the z axis movement on the fixed gantry if I needed to use the spindle in 3D.
As the only source of steppers at the moment is old printers or ebay(limited funds) the timing belts will give me my transmission.
I do have a supply of old display framing - aluminium extrusion - so I plan to use 19mm chrome steel tube ( wardrobe fitting dept) epoxyed into the channel. This will be bolted down onto an offcut slab of formica clad 38mm kitchen worktop.
I'm using miniature bearing from the scrap box augmented from ebay, but would try skate bearing otherwise.
Any thoughts?