Hey there again Chris, funny you should mention that as I only suggested Mach's "KeyGrabber" facility a day or so ago in another thread but again I too also wouldn't have known only for Hoss.....but getting back to your query you can allocate a particular key on your PC's keyboard to any function within Mach like for example the Spindle on/off is controlled by depressing key "F5" and this is called a "HotKey" I'll have a look for the links to explain this feature but in your case you could allocate any keyboard key for your green "cycle start" and this would save the mouse movement which I agree can be a bit of a PITA
oh and BTW Bob has a link to slot/arcade gaming machines push buttons too on his CNCcookbook site too...