Gusseting would be angle plates that span an inside corner which strengthens that corner. If you use t-slot, they make pre-made gusseting and plates; or you can make them yourself out of aluminum plate.
By spacing the trucks, I mean along each rail. For the gantry legs you'd want the trucks spaced such that the center of gravity of the gantry falls somewhere between the two trucks, or else one will wear faster than the other. This is more important at higher speed. Also you'll need a pretty beefy spindle to cut wood at speed.
You won't be able to cut aluminum slowly; the higher speeds of woodworking spindles dictate higher speeds (and maybe lower depth of cut) for aluminum. I cut aluminum frequently on my machine. the key is using the right tooling and choosing the right toolpaths (almost always climb milling) to get the chips to flow away from the toolpath.
There's a lot to be said about using steel tubing and plates for higher-speed wood cutting, and indeed there's merit to that. I cut at a relatively brisk rate for my machine and spindle (about 125-150ipm and 3/8"
doc with a 1/2" single-flute endmill) though my machine is not the stiffest. I simply allow for "spring away" with my roughing passes by climb-milling, and do my finish passes conventional milling at a slower federate.
Here's some vids of my machines cutting:
https://www.youtube.com/user/AtienzaLouie