How the big boys do it.
They don't worry about backlash, well sort of.
Investigation on a large machine, showed it had a drag brake with sufficient friction to take all cutting loads.
The axis has a shaft resolver, which doesn't suffer backlash.
Now a SERVO motor, using brute force drives the thing to where ever it should be.
As long as the response time is fast enough, there is no apparent backlash.
This is how the big lathes, with positional chuck capabilities get their precision.
They just use, say the 25HP Drive motor (a servo in effect) to move as required, running against the drag brake.
BINGO - No backlash, and no backlash settings.
Achieving this with a stepper motor is rather impractical.
Stepper systems are open loop. Servos are CLOSED loop.
If you can find a CLOSED loop stepper system, then that would be a good way to go.
Super X3. 3600rpm. Sheridan 6"x24" Lathe + more. Three ways to fix things: The right way, the other way, and maybe your way, which is possibly a faster wrong way.