I (we) have and was it worth it.....yes if only for the Simulate aspect and the fairly cheap upgrade. I still run through predator for the final program.
I only use the 3D features and it seems very good at that but then again I had no real problems with V23.
There are a few niggle bits with V25 that I recall were much simpler and easier in V23 but once you know about them all is OK.
If you have V23 tool features they will all have to be converted manually to the V25 standard which takes a little time.
Otherwise I am happy and it keeps us up to date.
V25, Dell T3700 Xeon, 16GB, Nvidia 4000, Win 7 64bit 2 x 22" Dell Monitors.
Moulds completed: 130