Joe200che, The design is, um, designed to be used in the plain shown, that is with the support at the side. There is enough room drawn for a max 12mm wide support, but that's with no clearance! I plan on using 10mm dia pillars as found necessary.
Skate-o-rail is supported sideways so that it can have a cover over it as shown in the drawing cross-section.
Of course you're free to hash it about for your purpose as you see fit...
WilliamD; Skate-o-rail does has means of adjustment, the bottom 2 bearing mounting holes are slotted and in this design it will accomodate either 1 inch or 25mm bar/tube.
I guess you could use 3 sets each side but I really don't think its necessary, The sensible thing is to keep weight on the gantry to a minimum as "porky" gantrys will cause problems cutting sharp corners and excess strain on the drive train.
Good feedback - carry on