We strongly recommended (January 1st, 2016) that you use Mach3 version 3.043.062 (click to download). The .062 release is the lock down version that works well, fixing stability issues experienced by people running version .066.
The latest release was Mach3 version 3.043.066. However, a number of people have had stability issues with their systems when using version .066. The .066 version has had these issues for some users:
MPG issues (we have seen this many times)
Pendent issues (we have seen this many times)
Feed hold issues
Homing issues
Macros not being fully run
VB buttons being ignored
If you are using v.066, we will tell you to install v.062 as the first step before we do anything else in term of support.