If you are tapping it to (I will refer to it in Imperial, as I am not real familiar with metric) say, 1/4" fine thread, then maybe. Anything much larger, and you will not have enough thread to make it happen.
My suggestions: center punch the initial hole, of course, drill it out to 1/4"
and then either:
1. Get a hole saw and some DOM tubing you can thread, and hole saw through the tubing, insert the threaded DOM, and weld up the DOM inside the box
or
2. Cut a hole with whatever size hole saw, and drill out the pilot hole to whatever size your bolt will be, on the circle piece you cut out. Weld a nut to this circle piece, put it back in place, get it exactly where you want it, and burn it back into place.
or
3. Drill all the way through the box, and just put the nut on the backside of the tube.
Not real sure what you are trying to do, so I don't know if any of this will work.
(Note: The opinions expressed in this post are my own and are not necessarily those of CNCzone and its management)
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