CNC it.
METHOD 1:
Use a piece of 1/4" fine MDF.
Rout a vacumuum grid in it. I assume the machine is CNC? It doesn't take very long with a stubby broken 1/8" drill bit router (or aircraft type panel drill bit for off the shelf) to make some vacuum grooves on a 1" grid.
Drill just through with normal PCB typ carbide drills.
They have a very flat tip angle, so it takes a while to destroy table.
You could put some vacuum groves under the MDF to match your table to keep the MDF flat or use super glue in a few spots.
METHOD 2:
PCB manufacturers often place a piece of scrap PCB top and bottom so that break through and edges stay perfect.
PCB drilling machines/routers have an arrangement on the drill head that presses down on the PCB near the hole being drilled. They often only locate the PCB with a few pins and a bit of tape. All the Z axis control is done by the head. An array of three or 4 castering sping loaded rollers will hold the PCB down for routing.
4 small air cyclinders (10mm OD) with off centre rollers running very low pressure will work nicely and they are easy to retract.
This is much less work than vacuum method. Vacuum systems and fiberglass dust are incompatible anyway.
Now the only thing that sucks is the dust extractor.
Super X3. 3600rpm. Sheridan 6"x24" Lathe + more. Three ways to fix things: The right way, the other way, and maybe your way, which is possibly a faster wrong way.