Mastercam Router and Mastercam Art would work nicely. There are also some great scripts for creating family of parts automatically in Router, (including geometry AND toolpaths!).
Haven't looked at the cost for both, but as a cheeper alternative, there's a fairly decent priced c-hook to do raster-to-vector conversions in MC Router, for any artwork you do.
You might consider going over to eMastercam.com and asking a few questions. (They'll be extremely biased to MC, but you'll get all the answers you want.)
Matt
San Diego, Ca
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(Note: The opinions expressed in this post are my own and are not necessarily those of CNCzone and its management)