If I was going to build one out of wood, I would use a Baltic Birch veneer plywood. I have seen 3/4" plywood with up to 15 plys. Great stuff to use, very stable but can be hard to find though. I get most of mine from shipping crates coming in from Denmark and Germany. Sometimes you can find it in specialty hardwood lumber stores. As for sealing it up I use a 2 part epoxy thinned with acetone (1:1) for the first coat and not thinned for the second and succesive coats.
I have seen somewhere in the gallery that there is a router made out of a phenolic resin. The gantry uprights were out of 3/4" sheet, red or pink in color.
The router that I'm building now it too big for the use of wood, I'm using aluminum and steel.
If it's not nailed down, it's mine.
If I can pry it loose, it's not nailed down.