Hi Sky....LOL.....this making a machine to make a machine is like the movie about the rise of the robots.......once a robot became a bit intelligent it went on to create itself but with enhanced characteristics that in the end gave birth to the super Big Daddy robot.
I think you are right in the SVM-0 thinking in keeping it within the bounds of it's envelope without stressing the other factors that make it a precision mill.
For my interest point of view, I would keep the ER32 spindle as the main standard offering, and have options available for ISO20 and the 65mm diam 6,000 rpm engraving spindle with the whatever ER end, probably ER11, whatever.
If it's possible to gild the lily any further, I would opt for a double nut ballscrew on the X axis, (even though it does reduce the table travel by a smidgeon), as in this area more back and forth travel is performed with the longer travel distance and this can only increase the wear in the nut, whereas the Y axis only has a short travel, so not so much wear would be encountered.......the Z is the least wear prone, even though it has to bear the whole weight of the head with inertia loads, and as a gas strut takes care of the direct weight a single nut would suffice.
I think the enclosure could be an option too, but if it's successfully arrived at it would be a valuable asset to maintenance in the swarf area.
I think also if Mist cooling were to be the preferred coolant source, the enclosure could be sectionalised and user assembled from preformed jointed panels with Silicon to seal the joints......and lots of window area would make it light and visible to view the progress, as most of the users would not be so blasé when it comes to seeing the machine walk the talk etc, and would like to see it in operation, unless you were doing CNC for a full time occupation and only wanted to press the green button when the red light flashes.....LOL.....no fun in that.
A full enclosure would be nice, but I think it would be difficult to ship without the packing case becoming huge.
If a full enclosure is on the cards, then consideration must be taken for those that want to attempt to fit some form of power draw bar mechanism for QTC options, and that could be easy if a panel were removable or just cut out of the top of the cabinet, so no big drama there.
There should be adequate clearance in the door opening area, as a too cramped opening will make life hard......the distance between the outside of an average person's body with arms by their sides would be an indication of how much room is needed when you are half inside the enclosure changing cutters and setting up jobs etc.
That is why I was interested in the Levil LW400 enclosure system with the drop down front panel etc, although having a fully enclosed enclosure and the door sliding sideways off to the side would give plenty of access......no doubt you will surprise us with a cool design as usual.
Ian.