I should also add that I had been using this CNC machine, configured exactly the same way, with this exact UC100, on a laptop running Windows 7 and Mach3, reliably for the last two years. The only reason I switched to this Windows 10 desktop is that the dust was causing the laptop's fan to get stuck and it was overheating causing shutdowns mid-run. I am willing to consider that there is something weird about this computers USB hub, but the fact that it seems to work with Mach3 points to a problem with the UCCNC and its firmware.
I should also add that I had been using this CNC machine, configured exactly the same way, with this exact UC100, on a laptop running Windows 7 and Mach3, reliably for the last two years. The only reason I switched to this Windows 10 desktop is that the dust was causing the laptop's fan to get stuck and it was overheating causing shutdowns mid-run. I am willing to consider that there is something weird about this computers USB hub, but the fact that it seems to work with Mach3 points to a problem with the UCCNC and its firmware.